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Updated: Jul 24, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Gamma interferon is critical for resistance to Theiler's virus-induced demyelination
M Rodriguez1, K Pavelko, R L Coffman
1Department of Neurology, Mayo Medical School, Rochester, Minnesota 55905, USA.
Abstract:
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.
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