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High-resolution B-mode ultrasonography in evaluation of atherosclerosis in uremia

T Kawagishi1, Y Nishizawa, T Konishi

  • 1Second Department of Internal Medicine, Osaka City University Medical School, Japan.

Kidney International
|September 1, 1995
PubMed

Insights

Uremic patients on hemodialysis show accelerated atherosclerosis, with age, smoking, and uremia as key risk factors. Elevated serum phosphorus and parathyroid hormone levels also contribute to arterial thickening.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Uremia is associated with increased cardiovascular disease risk.
  • Accelerated atherosclerosis is a concern in patients undergoing maintenance hemodialysis.
  • Identifying atherosclerosis risk factors in hemodialysis patients is crucial for clinical management.

Purpose of the Study:

  • To investigate if atherosclerosis is accelerated in uremic patients on maintenance hemodialysis.
  • To identify risk factors for carotid and femoral atherosclerosis in this patient population.

Main Methods:

  • High-resolution B-mode ultrasonography used to measure intima-media thickness (IMT).
  • Study included 199 hemodialysis patients and 81 healthy controls.
  • Multiple regression analysis employed to determine independent risk factors.

Main Results:

  • Hemodialysis patients exhibited significantly higher IMT in carotid and femoral arteries compared to controls.
  • Age, cigarette smoking, and uremic state were independent risk factors for atherosclerosis in both groups.
  • In hemodialysis patients, serum phosphorus and m-PTH levels were associated with IMT of carotid and femoral arteries, respectively.

Conclusions:

  • Maintenance hemodialysis may accelerate atherosclerosis.
  • Age, smoking, uremia, serum phosphorus, and m-PTH are significant risk factors for atherosclerosis in hemodialysis patients.
  • These findings highlight the need for aggressive management of cardiovascular risk factors in uremic patients.

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