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Early mucosal gastric cancer with lymph node metastasis
1Department of Gastroenterology, Kurume University School of Medicine, Japan.
The Kurume Medical Journal
|January 1, 1995
Summary
Early gastric cancer (m-cancer) rarely metastasizes to lymph nodes (2.2%). When metastasis occurs, tumors are larger and patients are younger, often presenting as type IIc with ulceration.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Early gastric cancer (m-cancer) is defined as cancer confined to the mucosa.
- Resection is a primary treatment for m-cancer.
- Lymph node metastasis is a critical prognostic factor.
Purpose of the Study:
- To investigate the incidence and characteristics of lymph node metastasis in early gastric cancer.
- To identify risk factors associated with lymph node metastasis in m-cancer.
Main Methods:
- Retrospective analysis of 358 early gastric cancer cases treated by resection.
- Evaluation of tumor diameter, patient age, macroscopic type, and presence of ulcer/ulcer scar.
- Comparison of characteristics between cases with and without lymph node metastasis.
Main Results:
- A total of 358 m-cancer cases were analyzed.
- Lymph node metastasis was observed in 8 cases (2.2%).
- Cases with lymph node metastasis (n(+)) had larger mean tumor diameter (5.2 cm vs. 2.75 cm) and younger mean age (51.6 years vs. 59.6 years).
- Seven of 8 n(+) cases were macroscopic type IIc and associated with ulcer and/or ulcer scar.
Conclusions:
- Lymph node metastasis is uncommon in early gastric cancer but associated with specific clinicopathological features.
- Macroscopic type IIc with ulceration may indicate a higher risk of lymph node metastasis in m-cancer.