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[New cytostatics and their clinical application (author's transl)]
Archiv Fur Geschwulstforschung
|January 1, 1978
Summary
This review covers cytostatic agents, focusing on established drugs with recent clinical significance. It details their chemistry, action, pharmacokinetics, dosage, side effects, and treatment outcomes.
Area of Science:
- Oncology
- Pharmacology
- Medicinal Chemistry
Context:
- Review of cytostatic agents in cancer therapy.
- Focus on drugs with historical presence and recent clinical relevance.
Purpose:
- To provide a comprehensive overview of cytostatic agent development and clinical evaluation.
- To detail chemical structure, mechanism of action, pharmacokinetics, dosage, side effects, and clinical outcomes for key agents.
Summary:
- Discusses adriamycin, nitrosoureas, DTIC, dibromdulcitol, trofosfamide, ifosfamide, ftorafur, 5-azacytidine, platinum complexes, ICRF-159, cytembena, HMM, VM 26, VP 16-213, cytostasan, estramustine phosphate, and antibody-cytostatic complexes.
- Highlights agents with growing clinical importance despite long-standing knowledge.
- Covers essential pharmacological and clinical data for each agent.
Impact:
- Informs oncologists and researchers on the current status and application of various cytostatic drugs.
- Aids in understanding the therapeutic potential and limitations of established and emerging chemotherapy agents.
- Provides a valuable reference for drug development and clinical trial design in cancer treatment.