Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interpreting nerve morphometry data after experimental traumatic lesions

L de Medinaceli1

  • 1European Institute of Biomaterials and Microsurgery, CHU de Nancy-Brabois, Vandoeuvre-lès-Nancy, France.

Journal of Neuroscience Methods
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional assessment of misdirected axon growth after nerve repair in the rat.

Journal of reconstructive microsurgery·2000
Same author

Functional consequences of isolated nerve stretch: experimental long-term static loading.

Journal of reconstructive microsurgery·1997
Same author

Cold and post-traumatic pain: modeling of the peripheral nerve message.

Bio Systems·1997
Same author

Statistical analyses and reliability of the sciatic functional index.

General pharmacology·1996
Same author

Large amounts of polylactic acid in contact with divided nerve sheaths have no adverse effects on regeneration.

Journal of reconstructive microsurgery·1995
Same author

Transplantation of a cryopreserved hindlimb in the rat.

Journal of reconstructive microsurgery·1993

Morphometric analysis of rat sciatic nerves after injury reliably shows nerve health but doesn't predict functional recovery. This research aids understanding of nerve regeneration outcomes.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Experimental Biology

Background:

  • Nerve injury, such as crush or transection, significantly impacts peripheral nerve function.
  • Assessing the outcomes of nerve repair and regeneration is crucial for developing effective therapeutic strategies.

Purpose of the Study:

  • To evaluate the utility of morphometric data in assessing the trophic state of regenerated peripheral nerves.
  • To compare the correlation between morphometric data and functional recovery after sciatic nerve injury and repair in rats.

Main Methods:

  • Induction of sciatic nerve crush lesions and transection with repair in a rat model.
  • Collection and analysis of morphometric data, utilizing ratios for clarity.
  • Comparison of morphometric findings with results from a functional assessment method.

Related Experiment Videos

Main Results:

  • Morphometric data provided a dependable indicator of the trophic status of regenerated nerves.
  • No significant correlation was observed between morphometric parameters and the achieved level of nerve function.

Conclusions:

  • Morphometric analysis is a valuable tool for evaluating the structural and trophic aspects of nerve regeneration.
  • Functional outcomes after peripheral nerve injury and repair may not be directly predictable from morphometric data alone.