Related Experiment Video
Updated: Jul 19, 2026

Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells
Published on: December 3, 2015
Expression of AML1 and ETO Transcripts in hematopoietic cells
1Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Abstract:
Recently, two genes, AML1 and ETO have been isolated from the chromosomal breakpoint of t(8;21). In this study, we isolated and identified fusion transcripts from a leukemic cell line carrying t(8;21). We demonstrated by PCR analysis that these transcripts are consistently expressed in fresh leukemic cells with t(8;21). On the other hand, the wild type of ETO is expressed in several hematopoietic cells from different lineage, while the expression of AML1 was present in all hematopoietic cells investigated. These widespread expression suggests these molecules play an essential role in hematopoiesis.
Related Concept Videos
Hematopoiesis
Multipotency of Hematopoietic Stem Cells
Lineage Commitment
Erythropoiesis
Regulation of Hematopoietic Stem Cells
Production of Formed Elements
Most HSCs commit to...

