Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomerase activity in human brain tumours

L A Langford1, M A Piatyszek, R Xu

  • 1Department of Pathology (Neuropathology), University of Texas, MD Anderson Cancer Center, Houston, USA.

Lancet (London, England)
|November 11, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interactions between genes and environment.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same author

The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: implications for deep space missions, female crews, and potential antioxidant countermeasures.

bioRxiv : the preprint server for biology·2024
Same author

Retraction Note: OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation.

Cell death & disease·2022
Same author

Differential Kras<sup>V12</sup> protein levels control a switch regulating lung cancer cell morphology and motility.

Convergent science physical oncology·2017
Same author

ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection.

Annals of the ICRP·2016
Same author

ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection.

Annals of the ICRP·2015

Telomerase activity is detected in most oligodendrogliomas and glioblastomas, suggesting these brain tumors may be immortal. Some gliomas, however, show absent telomerase, indicating different progression pathways.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Malignant gliomas are aggressive brain tumors known for invasiveness and resistance to treatment.
  • Telomerase is an enzyme crucial for maintaining telomere length, potentially enabling unlimited cellular proliferation and immortality.

Purpose of the Study:

  • To investigate the role and prevalence of telomerase activity in various human glioma subtypes.
  • To determine if telomerase activity correlates with specific glioma types and their progression.

Main Methods:

  • Analysis of telomerase activity in a cohort of 90 human glioma samples.
  • Categorization of gliomas into subtypes including oligodendrogliomas, glioblastoma multiformes, and anaplastic astrocytomas.

Main Results:

Related Experiment Videos

  • Telomerase activity was detected in all analyzed oligodendrogliomas (19/19) and a majority of glioblastoma multiformes (38/51).
  • Absence of telomerase activity was observed in anaplastic astrocytomas (2/20) and a subset of glioblastomas (13/51).

Conclusions:

  • The presence and absence of telomerase activity highlight distinct neoplastic progression pathways among glioma subtypes.
  • A specific subgroup of brain tumors comprises transformed cells that are pre-immortal, lacking detectable telomerase activity.