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Hemostatic function in young subjects with central obesity: relationship with left ventricular function

G Licata¹, R Scaglione, G Avellone

¹Department of Internal Medicine, University of Palermo, Italy.

Metabolism: Clinical and Experimental

|November 1, 1995

Summary

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Young obese individuals with central fat distribution exhibit altered coagulation and fibrinolysis, impacting left ventricular function. These changes include elevated clotting factors and reduced cardiac efficiency, highlighting risks associated with obesity.

Area of Science:

Cardiology
Metabolic Health
Hematology

Background:

Obesity, particularly central fat distribution, is linked to cardiovascular disease.
Coagulation and fibrinolysis play critical roles in cardiovascular health.
The impact of central obesity on cardiac function and hemostasis in young adults requires further investigation.

Purpose of the Study:

To evaluate coagulation and fibrinolysis activity in young obese subjects with central fat distribution.
To assess the relationship between these hemostatic parameters and left ventricular function.
To compare these measures against lean individuals.

Main Methods:

Assessed coagulation/fibrinolysis markers (Factor VII, fibrinogen, plasminogen, PAI, tPA) basally and post-occlusion.

Related Experiment Videos

Measured metabolic markers (glucose, lipids, insulin, apo A1/B).

Evaluated left ventricular function (LVEF, PFR) and mass (LVM/H); assessed central obesity via WHR.

Main Results:

Obese subjects showed higher Factor VII, fibrinogen, plasminogen, PAI, tPA1, glucose, apo B, and insulin.
Obese subjects exhibited lower HDL cholesterol, tPA2, LVEF, and PFR.
WHR correlated with fibrinogen and tPA2; LVEF with tPA1, PAI, fibrinogen; PFR with Factor VII activity.

Conclusions:

Young obese individuals with central obesity display a prothrombotic state and impaired fibrinolysis.
These hemostatic alterations are associated with reduced left ventricular function.
Central obesity significantly impacts both cardiovascular and hemostatic systems in young adults.