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Cure of prophage in Staphylococcus aureus by furocoumarin photoadditions
S M Cavalcanti1, J P Siqueira Júnior
1Departamento de Biologia Molecular/CCEN, Universidade Federal da Paraiba, Brazil.
Microbios
|January 1, 1995
Abstract:
In a previous report curing of prophage in Staphylococcus aureus by treatment with 8-methoxypsoralen plus near-UV (365 nm) radiation was described. In the present work the use of angelicin and 4,5',8-trimethylpsoralen and repeated irradiation show that monoadducts and DNA interstrand cross-links formed by furocoumarin photoaddition are involved in the curing of the prophage responsible for the suppression of the lipolytic activity in a putative repair proficient strain of Staphylococcus aureus.