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[Apoptosis in the African swine fever virus-swine mononuclear phagocyte system]

V V Makarov

    Molekuliarnaia Genetika, Mikrobiologiia I Virusologiia
    |July 1, 1995
    PubMed

    Insights

    African swine fever virus induces apoptosis, a form of cell death, in mononuclear phagocytes. This occurs when cells are treated with defective interfering virus particles or targeted by cytotoxic T-lymphocytes.

    Area of Science:

    • Virology
    • Cell Biology
    • Immunology

    Context:

    • African swine fever virus (ASFV) infects mononuclear phagocytes, crucial immune cells.
    • Understanding ASFV-induced cell death mechanisms is vital for disease control.

    Purpose:

    • To investigate the morphological characteristics of apoptosis induced by ASFV in mononuclear phagocytes.
    • To describe the cellular changes during ASFV infection and immune-mediated cell death.

    Summary:

    • Electron microscopy revealed apoptosis in ASFV-infected mononuclear phagocytes.
    • Apoptosis was observed in cultures treated with defective interfering ASFV particles.
    • Virus-specific cytotoxic T-lymphocytes also induced apoptosis in ASFV-infected target cells.

    Impact:

    • Provides detailed morphological insights into ASFV-induced apoptosis.
    • Contributes to understanding ASFV pathogenesis and host immune responses.
    • Informs potential therapeutic strategies targeting ASFV-induced cell death.

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