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Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
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Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

Inflammatory pseudocyst associated with trisomy 21 and Hirschsprung's disease

J J DuBois1, J Cheng, W J Pokorny

  • 1Baylor College of Medicine, Section of Pediatric Surgery, Houston, TX, USA.

Military Medicine
|September 1, 1995
PubMed

Insights

A rare inflammatory abdominal pseudocyst developed in a child with trisomy 21 and Hirschsprung's disease one month post-Swenson pull-through surgery. This case highlights a novel complication following surgical repair for Hirschsprung's disease.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Genetics

Background:

  • Hirschsprung's disease is a congenital disorder affecting the large intestine.
  • Surgical repair, such as the Swenson pull-through procedure, is standard treatment.
  • Abdominal pseudocysts are known complications in various medical contexts.

Observation:

  • A 15-month-old male with trisomy 21 and Hirschsprung's disease presented with an inflammatory abdominal pseudocyst.
  • The pseudocyst developed one month after undergoing a Swenson pull-through repair.
  • This occurred despite no prior history of conditions typically associated with pseudocysts.

Findings:

  • This is the first reported instance of an abdominal pseudocyst arising post-Hirschsprung's disease surgical repair.
  • The pseudocyst formation was noted one month after the Swenson procedure.
  • The patient had concurrent trisomy 21, a factor not previously linked to this complication.

Implications:

  • This case expands the differential diagnosis for abdominal masses in pediatric patients post-Hirschsprung's repair.
  • It suggests a potential, albeit rare, association between surgical intervention for Hirschsprung's disease and pseudocyst development.
  • Further investigation may be warranted to understand the specific mechanisms and risk factors involved.

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