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Decrease in synapsin I staining in the hypogastric ganglion of aged rats

A L Warburton1, R M Santer

  • 1School of Molecular and Medical Biosciences (Anatomy Unit), University of Wales College of Cardiff, UK.

Neuroscience Letters
|July 21, 1995
PubMed
Summary
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Aging significantly reduces nerve terminal markers in sympathetic neurons within the rat hypogastric ganglion (HG), impacting autonomic control of pelvic viscera. Parasympathetic neurons showed no such age-related changes.

Area of Science:

  • Neuroscience
  • Autonomic Nervous System Research
  • Aging Studies

Background:

  • The hypogastric ganglion (HG) innervates pelvic viscera with sympathetic and parasympathetic neurons.
  • Tyrosine hydroxylase (TH) and NADPH-diaphorase (NADPH-d) identify sympathetic and parasympathetic neurons, respectively.
  • Synapsin I is a marker for nerve terminals.

Purpose of the Study:

  • To investigate the impact of aging on synapsin I distribution in relation to sympathetic and parasympathetic neurons in the rat HG.
  • To determine if age affects synaptic integrity and autonomic control of pelvic viscera.

Main Methods:

  • Immunohistochemical staining for TH, NADPH-d, and synapsin I in young adult and aged rat HGs.
  • Image analysis to quantify synapsin I staining intensity relative to neuronal populations.

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Main Results:

  • Synapsin I staining, primarily axosomatic, was markedly reduced in aged rats.
  • A ~50% reduction in synapsin I was observed in relation to sympathetic (TH-positive) neurons.
  • No significant change in synapsin I staining was found for parasympathetic (NADPH-d-positive) neurons.

Conclusions:

  • Aging compromises synaptic transmission and peripheral integration in the hypogastric ganglion.
  • Sympathetic innervation of pelvic viscera is particularly affected by aging.
  • Autonomic control of pelvic viscera may be impaired in old age due to reduced sympathetic nerve terminal function.