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The iron-copper connection: the link to ceruloplasmin grows stronger
1Department of Biochemistry and Biophysics, Faculty of Nutrition, Texas A&M University, College Station 77843-2128, USA.
Nutrition Reviews
|June 1, 1995
Abstract:
A rare genetic defect in ceruloplasmin biosynthesis has provided the strongest evidence to date that ceruloplasmin is essential for iron metabolism and tissue distribution in humans. A aceruloplasminemia results in massive accumulations of iron in the liver and brain and is associated with retinal degeneration and diabetes.