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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Mitsuokella dentalis in human periodontitis
1University of Southern California, School of Dentistry, Los Angeles 90089-0641, United States.
Oral Microbiology and Immunology
|August 1, 1994
Summary
Mitsuokella dentalis was detected in human periodontitis using culture and DNA probes. This bacterium is part of the pathogenic microbiota, though its role in periodontitis is still unknown.
Area of Science:
- Microbiology
- Periodontology
- Oral Health
Background:
- Periodontitis is a complex oral disease associated with specific bacterial pathogens.
- The role of Mitsuokella dentalis in the development and progression of periodontitis requires further investigation.
Purpose of the Study:
- To determine the occurrence of Mitsuokella dentalis in subgingival plaque of periodontitis patients.
- To characterize the biochemical properties and antibiotic sensitivity of M. dentalis isolates.
Main Methods:
- Subgingival plaque samples were collected from 480 periodontitis patients using paper points.
- Mitsuokella dentalis was detected using both anaerobic culture techniques and a specific DNA probe assay.
- Biochemical profiling and in vitro antibiotic susceptibility testing (metronidazole) were performed.
Main Results:
- Culture methods identified M. dentalis in 18.1% of patients, while DNA probe detection found it in 80.7%.
- M. dentalis isolates exhibited enzymatic activity (phosphatases, galactosidase, glucosidase, acetylglucosaminidase).
- Isolates showed high in vitro sensitivity to metronidazole.
Conclusions:
- Mitsuokella dentalis is a common component of the pathogenic microbiota in human periodontitis.
- The specific periodontopathic potential of M. dentalis remains to be elucidated.
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