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Related Experiment Videos

cis-Platinum ototoxicity

L Helson, E Okonkwo, L Anton

    Clinical Toxicology
    |January 1, 1978
    PubMed
    Summary

    Cis-platinum chemotherapy can cause hearing loss (ototoxicity), particularly at higher frequencies. Younger patients experience less hearing damage from cis-platinum than older patients.

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    Area of Science:

    • Ototoxic effects of chemotherapy
    • Cancer treatment side effects
    • Audiology and hearing science

    Background:

    • Cis-platinum is a widely used chemotherapy agent for various cancers.
    • Ototoxicity is a known, significant side effect of cis-platinum treatment.
    • Understanding the spectrum and incidence of ototoxicity is crucial for patient management.

    Purpose of the Study:

    • To determine the incidence and specific frequencies affected by cis-platinum-induced ototoxicity.
    • To investigate the influence of patient age and drug dosage on ototoxicity.
    • To evaluate the potential protective effects of prehydration and mannitol infusion.

    Main Methods:

    • Audiographic evaluation of pure tone thresholds (500-8000 Hz) in 104 cancer patients.
    • Pre-treatment and post-treatment hearing assessments were conducted.
    • Analysis of hearing changes in relation to patient age and cis-platinum dosage.

    Main Results:

    • Ototoxicity was observed, with the highest sensitivity at 6000 and 8000 Hz.
    • Younger patients exhibited lower hearing threshold increases per dose compared to older patients.
    • Higher cis-platinum dosages resulted in greater threshold elevations and affected lower frequencies.

    Conclusions:

    • Cis-platinum administration can lead to significant ototoxicity, especially at high frequencies.
    • Age and drug dosage are critical factors influencing the severity of hearing loss.
    • Regular audiographic monitoring is essential for cancer patients undergoing cis-platinum therapy.

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