Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Severe neurotoxicity and lithium therapy

H T Pi, F G Surawicz

    Clinical Toxicology
    |January 1, 1978
    PubMed
    Summary

    Lithium treatment can cause severe neurotoxicity and kidney issues, especially in hot weather. Propranolol effectively treated persistent hypertension and tremors linked to lithium toxicity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Expression of MSI1 and HER2 in mammary Paget's disease and their correlation with clinicopathological features and prognosis].

    Zhonghua bing li xue za zhi = Chinese journal of pathology·2023
    Same author

    Further Studies in Adult Rickets (Osteomalacia) and Fœtal Rickets: (Section of Obstetrics and Gynæcology).

    Proceedings of the Royal Society of Medicine·2009
    Same author

    Cataract in Adult Rickets (Osteomalacia): (Section of Ophthalmology).

    Proceedings of the Royal Society of Medicine·2009
    Same author

    Schizo-affective disorder (Schneiderian positive), manic type: a comparison with mania.

    The Journal of clinical psychiatry·1982
    Same author

    Alcoholic hallucinosis: a missed diagnosis. Differential diagnosis and management.

    Canadian journal of psychiatry. Revue canadienne de psychiatrie·1980
    Same author

    Psychiatry and the female patient: some common pitfalls.

    The Alabama journal of medical sciences·1979

    Area of Science:

    • Nephrology
    • Neurology
    • Pharmacology

    Background:

    • Lithium is a common treatment for bipolar disorder.
    • Prolonged lithium use can lead to toxicity.
    • Environmental and physiological factors can influence lithium levels.

    Purpose of the Study:

    • To report a case of severe lithium toxicity.
    • To explore contributing factors to lithium toxicity.
    • To evaluate treatment outcomes for lithium-induced complications.

    Main Methods:

    • Case study of a patient with bipolar disorder on lithium therapy.
    • Analysis of clinical presentation and contributing factors.
    • Assessment of treatment response to propranolol.

    Main Results:

    • Patient developed neurotoxicity and glomerulonephritis-like syndrome.
    • Contributing factors identified: hot weather, gallbladder pathology, reduced fluid/salt intake.
    • Hypertension and tremor persisted after initial improvement.
    • Propranolol successfully managed hypertension and tremor.

    Conclusions:

    • Lithium toxicity can be precipitated by dehydration and fever.
    • Persistent hypertension and tremor can occur post-lithium toxicity.
    • Propranolol is effective in managing residual lithium-induced side effects.

    Related Experiment Videos