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[Concentration of chromium in blood serum of patients with chronic renal failure]
J Małecka1, W Grzeszczak, E A Zukowska-Szczechowska
1Specjalistyczny Szpital Miejski, Stalownik, Bielsko-Biała.
Insights
Serum chromium levels are elevated in patients with chronic renal failure (CRF). Hemodialysis treatment effectively reduces these elevated chromium concentrations in CRF patients, indicating its impact on chromium levels.
Area of Science:
- Clinical Chemistry
- Nephrology
- Trace Element Analysis
Background:
- Patients with chronic renal failure (CRF) often exhibit altered trace element metabolism.
- Chromium is an essential trace element with potential implications in renal disease.
Purpose of the Study:
- To investigate serum chromium concentrations in patients with chronic renal failure (CRF).
- To evaluate the effect of hemodialysis on serum chromium levels in CRF patients.
- To explore correlations between serum chromium and other clinical parameters in CRF.
Main Methods:
- Serum chromium levels were measured in 66 CRF patients (hemodialysis and non-hemodialysis groups) and 16 healthy controls.
- Flame atomic absorption spectrophotometry was used for chromium analysis.
- Blood samples were collected at multiple time points for hemodialysis patients.
Main Results:
- Serum chromium concentration was significantly higher in CRF patients compared to healthy controls.
- Hemodialysis led to a significant decrease in serum chromium concentration.
- Significant correlations were observed between serum chromium and creatinine, hemoglobin, hematocrit, and erythrocytes.
Conclusions:
- Patients with chronic renal failure have elevated serum chromium levels.
- Hemodialysis is effective in reducing serum chromium concentration in CRF patients.
- Serum chromium levels in CRF patients are not significantly different between subgroups.
Unlabelled:
A group of 66 patients with chronic renal failure (CRF) was studied. 42 of them (21 to 63 years old) were treated with haemodialysis and 24 of them (20 to 63 years old) were treated without dialysis. A group of 16 healthy subjects, 19 to 73 years old, were also studied. The blood samples in non-hemodialyzed patients and healthy subjects were taken only once after cannula had been inserted into the antebrachial vein. The blood samples in hemodialyzed patients were withdrawn four times: just before dialysis, during haemodialysis after the first hour of dialysis (from the arterial and from venous line of the dialyser) and after haemodialysis. Chromium concentrations in serum in all examined groups and chromium concentrations in the dialysis fluid as well as in the demineralized water used for dialysis were measured by flame atomic absorption spectrophotometry. In all patients with CRF serum chromium concentration was significantly higher than in the controls. During haemodialysis a decrease of serum chromium concentration was observed. Significant correlations between chromium concentration and creatinine concentration, haemoglobin concentration, haematocrit value, erythrocytes were observed.
Conclusions:
1. Serum chromium concentration in patients with CRF was significantly higher than in normals. 2. No significant differences were found in serum chromium concentration between subgroups of patients with chronic renal failure. 3. Haemodialysis decreases significantly serum chromium concentration.