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Seizure-induced activation of enkephalin- and somatostatin-synthesizing neurons
S Pretel1, C D Applegate, D T Piekut
1Department of Neurobiology and Anatomy, University of Rochester, School of Medicine and Dentistry, NY 14642, USA.
Abstract:
The extent of the neuronal network that is activated by kainic acid-induced seizures was anatomically identified and neurochemically characterized. Seizure-activated neurons were identified through the immunocytochemical demonstration of Fos protein in neuronal nuclei. These seizure-activated neurons were characterized by determining if they contained the mRNA for somatostatin or enkephalin, using in situ hybridization procedures. The results demonstrate that a majority of enkephalin- and somatostatin-synthesizing neurons expressed the Fos protein following seizures and that they represent a major component of the kainic acid-induced, seizure-activated neuronal network.