Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Primary osteosarcoma of the breast

S Remadi¹, I Doussis-Anagnostopoulu, W Mac Gee

¹Department of Clinical Pathology, University of Geneva, Faculty of Medecine, Switzerland.

Pathology, Research and Practice

|June 1, 1995

Summary

This study details a rare breast osteosarcoma case in an 83-year-old woman. Immunohistochemistry revealed tumor cells positive for vimentin and alpha-1-antitrypsin, suggesting a non-epithelial origin.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions.

Infectious agents and cancer·2016

Same author

[The therapeutic contribution of proteomic approaches in cancers].

Gynecologie, obstetrique & fertilite·2011

Same author

[Ovary tumor in chronic myeloid leukaemia. Case report].

Gynecologie, obstetrique & fertilite·2007

Same author

Cervical cancer and HPV.

La Tunisie medicale·2006

Same author

Glutathione S-transferases (GSTT1 and GSTM1) gene deletions in Tunisians: susceptibility and prognostic implications in breast carcinoma.

British journal of cancer·2003

Same author

Cervical human papillomavirus infection in Tunisian women.

Infection·2003

Area of Science:

Oncology
Pathology
Histopathology

Background:

Primary osteosarcoma of the breast is an exceptionally rare malignant bone tumor.
Distinguishing it from metaplastic carcinoma is crucial for accurate diagnosis and treatment.

Observation:

An 83-year-old woman presented with a rare case of primary breast osteosarcoma.
Immunohistochemical analysis utilized a comprehensive antibody panel to characterize tumor cells.

Findings:

Tumor cells demonstrated intense vimentin and focal alpha-1-antitrypsin immunoreactivity.
Absence of cytokeratin staining ruled out an epithelial component, excluding metaplastic carcinoma.
Multinucleated giant cells showed strong KP-1 antibody staining, indicative of a histiocytic origin.

Implications:

The findings suggest breast osteosarcoma may arise de novo or from transformation of benign breast lesions.
Further research is needed to elucidate the exact pathogenesis of primary breast osteosarcoma.
Accurate immunohistochemical characterization is vital for diagnosing rare breast malignancies.

Related Experiment Videos