[Analysis of the effects of selected polymers on morpho-dynamic features of rat hepatocytes]

The thesis shows the results of the research on the influence of the film-form polymers on the hepatocytes in rats. The polymers were composed of polyethylene (PE), polyvinyl chlorides (P-25, P-47), polyesters (A, B, E) and irradiated L7 collagen. The aim of the research was to establish whether the changes in the specific morpho-dynamic characteristics-which prove the changes in the hepatocyte metabolic activity in rats-could be used to assess the usability of the above mentioned polymers for medicine. The evaluation of the research findings was analysed on the basic of the stereometric methods and factor analysis. On the basic of the obtained results, polyvinyl chlorides P-25 and P-47 have been evaluated most favourably as far as their possible application in medicine is concerned, whereas polyester E shows the most negative characteristics for such an application.