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Related Experiment Videos

Mapping the mouse genome: current status and future prospects

W F Dietrich1, N G Copeland, D J Gilbert

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 21, 1995
PubMed
Summary
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The mouse is a key model for mammalian genetics, featuring a detailed genetic map with over 14,000 markers. This map aids in understanding physiology, development, and enables advanced genetic research.

Area of Science:

  • Genetics
  • Mammalian Physiology
  • Bioinformatics

Background:

  • The mouse is a premier model organism for studying mammalian genetics and physiology.
  • Genetic mapping in mice is crucial due to the feasibility and importance of genetic crosses.
  • Recent advancements have significantly expanded the mouse genetic map.

Purpose of the Study:

  • To highlight the current state and utility of the mouse genetic map.
  • To underscore the value of different marker types for genetic and physical mapping.
  • To discuss the implications for future research in mouse genetics and comparative genomics.

Main Methods:

  • Compilation and analysis of existing data on mouse genetic markers.
  • Description of marker types: mutant loci, genes, and simple sequence length polymorphisms (SSLPs).

Related Experiment Videos

  • Assessment of available physical mapping resources, such as yeast artificial chromosome (YAC) libraries.

    • Main Results:

    • The mouse genetic map comprises over 14,000 markers, including 700 mutant loci, 3500 genes, and 6500 SSLPs.
    • Mutant loci and genes provide insights into physiology and development.
    • SSLPs serve as polymorphic anchors for inheritance tracking and physical map assembly.

    Conclusions:

    • The current mouse genetic map is a valuable resource for diverse research areas.
    • While a comprehensive physical map is forthcoming, existing resources support positional cloning.
    • Comparative sequence analysis between mouse and human holds significant potential for understanding gene structure and regulation.