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Factors affecting success with intracytoplasmic sperm injection
M J Tucker1, P C Morton, G Wright
1Reproductive Biology Associates, Atlanta, GA 30342, USA.
Reproduction, Fertility, and Development
|January 1, 1995
Summary
Intracytoplasmic sperm injection (ICSI) significantly improves in vitro fertilization (IVF) success rates for couples with poor fertilization potential. This technique enables pregnancy even with surgically retrieved or immotile sperm, overcoming previous fertilization challenges.
Area of Science:
- Reproductive Medicine
- Embryology
- Infertility Treatment
Background:
- Conventional in vitro fertilization (IVF) can fail due to poor sperm quality or function.
- Intracytoplasmic sperm injection (ICSI) was developed to address fertilization issues in IVF.
- Assessing the efficacy of ICSI in a clinical setting is crucial for optimizing infertility treatments.
Purpose of the Study:
- To evaluate the success rates of in vitro fertilization (IVF) cycles utilizing intracytoplasmic sperm injection (ICSI).
- To determine the impact of patient factors, such as maternal age and previous fertilization failure, on ICSI outcomes.
- To assess the feasibility of using ICSI with various sperm sources, including surgically retrieved and immotile sperm.
Main Methods:
- A retrospective analysis of 163 in vitro fertilization (IVF) cycles using intracytoplasmic sperm injection (ICSI) in 141 couples.
- Tracking fertilization rates, embryo development, cryopreservation suitability, and pregnancy outcomes.
- Analyzing the influence of maternal age, prior fertilization failure, and sperm retrieval methods on success rates.
Main Results:
- Overall normal fertilization rate was 41%, with 81% of embryos suitable for transfer or cryopreservation.
- Fresh embryo transfers resulted in a 27.6% pregnancy per cycle rate, with a 10.7% implantation rate per embryo.
- Sperm from testis, epididymis, electro-ejaculation, and immotile ejaculated sperm all led to pregnancies; ICSI reinsemination for rescue had a low implantation rate (5%).
Conclusions:
- Intracytoplasmic sperm injection (ICSI) significantly enhances the success of in vitro fertilization (IVF) for couples with compromised sperm function.
- ICSI offers a viable option for utilizing sperm from various sources, including those previously considered untreatable.
- While ICSI improves fertilization rates, factors like maternal age and prior fertilization history remain significant predictors of overall success.