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[Herpes zoster in infants]

E Rivas de La Lastra1, M A Lasso Bonilla

  • 1CHMAAM, Caja de Seguro Social de Panamá.

Revista Medica De Panama
|January 1, 1995
PubMed
Summary

Maternal varicella during early pregnancy poses a risk for congenital malformations in infants. This study highlights potential risks associated with herpes zoster in children under two.

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Area of Science:

  • Pediatrics
  • Virology
  • Obstetrics

Background:

  • Varicella (chickenpox) infection during pregnancy can lead to adverse fetal outcomes.
  • Herpes zoster, caused by the varicella-zoster virus, is less common in infants but can occur.
  • Congenital malformations are a significant concern in prenatal viral infections.

Purpose of the Study:

  • To investigate the clinical presentation of herpes zoster in young children.
  • To explore the association between maternal varicella infection during pregnancy and congenital abnormalities in offspring.
  • To assess the risk of congenital malformations following maternal varicella exposure in early gestation.

Main Methods:

  • Retrospective case series of four children diagnosed with herpes zoster.
  • Analysis of maternal varicella infection timing during pregnancy.
  • Clinical evaluation of infants for congenital abnormalities at birth and during hospitalization.

Main Results:

  • Four children under two years old were hospitalized with herpes zoster.
  • Mothers reported varicella infection during the 3rd, 5th, 6th, and 8th months of gestation.
  • Infants whose mothers had varicella in the 3rd and 5th months of pregnancy exhibited low birth weight, with one also showing dysphagia and prematurity.

Conclusions:

  • Maternal varicella infection in the first trimester (e.g., 3rd month) is associated with an increased risk of congenital malformations.
  • Herpes zoster in infants may indicate prenatal exposure to varicella-zoster virus.
  • Further research is warranted to fully elucidate the teratogenic potential of early gestational varicella.

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