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[Reinfusion ascites therapy: considerations after a year's experience]
G E Russo1, M S Caramiello, E Vitaliano
1Policlinico Umberto I, Università La Sapienza, Roma.
Rivista Europea Per Le Scienze Mediche E Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Europeenne Pour Les Sciences Medicales Et Pharmacologiques
|May 1, 1994
Summary
This study introduces a novel ascites treatment combining double filtration of ascitic fluid and reinfusion of concentrated proteins (DFAF) with beta-interferon and ATIII infusion for refractory hepatic cirrhosis patients.
Area of Science:
- Gastroenterology
- Hepatology
- Internal Medicine
Background:
- Ascites is a common complication of various illnesses, often managed with diuretics, dietary changes, and paracentesis.
- Conventional treatments for ascites can be ineffective or lead to complications, necessitating alternative therapeutic strategies.
Purpose of the Study:
- To evaluate a novel therapeutic approach for managing ascites refractory to standard treatments.
- To assess the efficacy and safety of combining double filtration of ascitic fluid and reinfusion of concentrated proteins (DFAF) with beta-interferon and antithrombin III (ATIII) infusion.
Main Methods:
- A cohort of twenty patients with hepatic cirrhosis and refractory ascites received the combined treatment.
- The treatment involved the double filtration of ascitic fluid with reinfusion of concentrated proteins (DFAF), peritoneal injection of beta-interferon, and intravenous infusion of ATIII.
Main Results:
- All patients experienced immediate clinical improvement following the intervention.
- After one year, twelve patients required repeat DFAF treatment, six needed medication adjustments, and two patients succumbed to their underlying pathology.
Conclusions:
- The combined therapeutic strategy shows promise in managing refractory ascites in patients with hepatic cirrhosis.
- This novel approach offers an alternative to conventional therapies, potentially improving clinical outcomes and reducing the need for repeated interventions.