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[Multiple system atrophy with Lewy bodies]

F Tison1, G K Wenning, S E Daniel

  • 1University Department of Clinical Neurology, Hôpital Pellegrin, Bordeaux.

Revue Neurologique
|June 1, 1995
PubMed
Summary

Multiple system atrophy (MSA) and Parkinson's disease can present with overlapping symptoms, complicating diagnosis. Research suggests the co-occurrence of Lewy bodies in MSA may be coincidental, not clinically significant.

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Key themes and future prospects in translational multiple system atrophy research.

Autonomic neuroscience : basic & clinical·2017

Area of Science:

  • Neurology
  • Pathology

Background:

  • Multiple system atrophy (MSA) is a sporadic neurodegenerative disease affecting autonomic neurons and specific brain systems.
  • Distinguishing MSA from idiopathic Parkinson's disease (PD) can be challenging clinically and pathologically.

Observation:

  • Some MSA cases exhibit Lewy bodies, typically associated with PD, leading to diagnostic confusion.
  • This study reports three new cases of MSA with Lewy bodies from the UK Parkinson's Disease Society Brain Bank.

Findings:

  • Clinical and pathological data suggest the co-occurrence of Lewy bodies in MSA (transitional variant) may lack specific clinical significance.
  • The prevalence of Lewy bodies in MSA appears to be a chance association, similar to normal elderly individuals.

Implications:

  • While the association may be coincidental, further research is needed to rule out shared susceptibility factors for MSA and PD.
  • Clarifying the significance of Lewy bodies in MSA aids in accurate diagnosis and understanding of neurodegenerative disease overlap.

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