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E test: a novel technique for antimicrobial susceptibility testing

H S Sader¹, A C Pignatari

¹Department of Infectious and Parasitic Diseases of the Escola Paulista de Medicina, São Paulo, SP Brasil.

Sao Paulo Medical Journal = Revista Paulista De Medicina

|October 1, 1994

Summary

The E test provides a reliable method for determining antimicrobial susceptibility. This study evaluated its effectiveness for key bacterial pathogens against various drugs.

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Area of Science:

Microbiology
Clinical Pharmacy
Infectious Diseases

Background:

Accurate antimicrobial susceptibility testing is crucial for effective treatment of bacterial infections.
The E test is a commercially available method for determining minimum inhibitory concentrations (MICs).

Purpose of the Study:

To evaluate the applicability and performance of the E test for antimicrobial susceptibility testing.
To assess the E test's utility in determining MICs for specific bacterial pathogens.

Main Methods:

Literature review on the E test methodology.
In-house susceptibility testing of Xanthomonas maltophilia, Streptococcus pneumoniae, and Streptococcus viridans group using the E test.
Evaluation against eight different antimicrobial agents.

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Main Results:

The E test demonstrated applicability in determining antimicrobial susceptibility for the tested bacteria.
Results from the E test provided minimum inhibitory concentrations for various drug-bacteria combinations.

Conclusions:

The E test is a viable method for routine antimicrobial susceptibility testing in clinical laboratories.
Further studies are warranted to establish comprehensive E test breakpoints for emerging pathogens.