[Thrombophilia characterized by resistance to anticoagulants with indirect action]

The paper reports 2 cases of resistance to indirect-action anticoagulants used for prevention of thrombosis. One female patient combined resistance to fenilin with that to aspirin and trental, platelet hyperaggregation returned to normal due to ibustrin. The change of fenilin for pelentan did not influence the situation. In another case the resistance was to fenilin, but hypocoagulation was achieved with neodicumarin in standard doses. Platelet hyperaggregation was corrected by routine doses of aspirin. Causes of resistance to anticoagulants acting indirectly are discussed.