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Gene therapy to restore prostacyclin presence to injured endothelium
J T Willerson1, P Zoldhelyi, R Meidell
1University of Texas Health Science Center, Houston 77030, USA.
Abstract:
These preliminary studies demonstrate the feasibility of restoration of prostacyclin synthesis in mechanically-injured porcine carotid arteries following angioplasty. Our initial data suggest the possibility of inhibiting thrombus development by adenovirus-CMV-PGHS-1 therapy in the initial 10 days following angioplasty.