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Primary lymphoma of the thyroid
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Medical Journal
|September 1, 1995
Summary
Primary thyroid lymphoma is rare. This study suggests combined chemo-radiotherapy may be an effective initial treatment for thyroid lymphoma, even in early stages, based on outcomes and prognostic factors.
Area of Science:
- Oncology
- Endocrinology
- Hematology
Background:
- Primary thyroid lymphoma is an uncommon malignancy.
- Thyroid lymphoma can present with a neck mass and may be associated with Hashimoto's thyroiditis or hypothyroidism.
Purpose of the Study:
- To review the treatment outcomes and prognostic factors of primary thyroid lymphoma.
- To evaluate the efficacy of different treatment modalities.
Main Methods:
- Retrospective review of 5 primary thyroid lymphoma cases diagnosed between 1982 and 1994.
- Analysis of patient demographics, clinical presentation, histology, stage, treatment, and outcomes.
Main Results:
- All 5 cases presented with a neck mass; 2 had Hashimoto's thyroiditis, 3 were hypothyroid.
- All non-Hodgkin's lymphomas were intermediate grade, stages IE (1) and IIE (4).
- Surgery alone was used in 3 cases; chemo-radiotherapy in 2 bulky stage IIB cases, achieving complete/partial response with minimal toxicity.
Conclusions:
- Combined chemo-radiotherapy can be considered as an initial treatment option for thyroid lymphoma, including stage I and II.
- Prognostic factor evaluation is crucial for treatment decisions in thyroid lymphoma.