Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Drug-induced cholestasis]

G Pott1

  • 1Innere Abteilung, Marienkrankenhauses Nordhorn.

Zeitschrift Fur Gastroenterologie
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Drug-induced cholestasis affects about 2% of hospitalized patients with jaundice. Nearly any medication can cause this liver reaction, particularly newer drugs, necessitating careful consideration of drug intolerance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diagnosis of and therapy for hepatocellular carcinoma].

Zeitschrift fur Gastroenterologie·2013
Same author

[Palliative care in gastroenterology: why do we need it and how do we qualify?].

Zeitschrift fur Gastroenterologie·2009
Same author

[Gastroenterological palliative care].

Zeitschrift fur Gastroenterologie·2008
Same author

[When gastrointestinal symptoms present, consideration should always be given to celiac disease].

MMW Fortschritte der Medizin·2004
Same author

Endocytic delivery of intramolecularly quenched substrates and inhibitors to the intracellular yeast Kex2 protease1.

The Biochemical journal·1999
Same author

[Psychosomatic disorders in dermatology--incidence and need for added psychosomatic treatment].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·1998

Area of Science:

  • Hepatology
  • Clinical Pharmacology

Background:

  • Cholestasis is a liver reaction to drug intolerance, affecting an estimated 2% of hospitalized patients treated for jaundice.
  • Drug-induced liver injury is a significant clinical concern, with a distinction between obligatory and optional hepatotoxic substances.

Purpose of the Study:

  • To review the spectrum of drugs that can cause cholestasis.
  • To highlight the clinical importance of optional, more frequently encountered, drug-induced cholestasis.

Main Methods:

  • Literature review of drug-induced cholestasis.
  • Analysis of drug classes associated with cholestasis.

Main Results:

  • Nearly any drug can potentially cause cholestasis.

Related Experiment Videos

  • Optional (idiosyncratic) drug-induced cholestasis is more common clinically.
  • Specific drug classes frequently associated with cholestasis include antibiotics, antiarrhythmics, and antidepressants.

    • Conclusions:

    • Drug-induced cholestasis is a critical consideration in patient management, especially with new drug introductions.
    • Awareness of frequently implicated drug classes aids in diagnosis and prevention of liver injury.