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MMR vaccination, measles epidemiology and sero-surveillance in the Republic of Ireland

H Johnson1, I B Hillary, G McQuoid

  • 1Eastern Health Board, Community Care Area 2, Dublin, Ireland.

Vaccine
|April 1, 1995
PubMed
Abstract

Insights

Measles, mumps, and rubella (MMR) antibody levels varied in children post-vaccination. Sub-optimal MMR vaccine uptake necessitates a two-dose MMR program to prevent outbreaks in older children.

Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Public health

Background:

  • A national measles and MMR vaccination program was implemented.
  • Assessing vaccine effectiveness and disease epidemiology is crucial for public health policy.

Purpose of the Study:

  • To determine measles, mumps, and rubella susceptibility in children aged 3-14 years.
  • To correlate serological findings with measles epidemiology and inform vaccination policy.

Main Methods:

  • Cross-sectional sero-survey conducted in pediatric hospital outpatient departments in Dublin.
  • Sera collected from 837 children between 1991-1992.
  • Analysis of measles notification and mortality trends.

Main Results:

  • Antibody prevalence varied by age: measles (84-95%), mumps (48-65%), rubella (63-78%).
  • Mumps antibody prevalence might be underestimated.
  • Measles outbreak in 1993; increasing notifications in older children observed.

Conclusions:

  • Sub-optimal MMR vaccine uptake leads to inevitable outbreaks in younger children.
  • A high-uptake, two-shot MMR vaccination program is essential.
  • Preventing disease shift to older age groups is critical.

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