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Skeletal muscle ultrastructural and biochemical alterations induced by experimental hyperthyroidism
A Crespo Armas1, H J Finol, B Anchustegui
1Cátedra de Fisiología, Universidad Central de Venezuela, Caracas.
Acta Cientifica Venezolana
|January 1, 1993
Abstract:
Rats treated with high doses of T4 showed an increase in the oxygen consumption in state 3 rate respiration of mitochondria isolated from Soleus (slow twitch) and Extensor Digitorum Longus (EDL, fast twitch) muscles, without modification of either their phosphorylation efficiency (ADP/O ratio) or their coupling. Muscle fiber main alterations were atrophy and changes of the structure and shape of mitochondria. Also, abundant autophagic vacuoles with mitochondrial debris, myelin-like figures, glycogenosomes and primary lysosomes were found.