[Studies on CDDP-albumin microspheres for hepatic arterial chemoembolization]

An optimum procedure was established by orthogonal test for preparing cis-platin albumin microspheres (CDDP-AMS) with emulsion-heating stabilization method. The factors which affect particle size and release rate in vitro were studied. The particle size focusing on 58.8-256 microns, the mean size was 148.46 microns, drug content was 51.16% (w/w). The dissolution profiles of the CDDP-AMS followed Higuchi kinetics. In rabbits the distribution and elimination half times of platinum were prolonged 3.36 times and 1.23 times vs injection group, respectively, after hepatic arterial chemoembolization with CDDP-AMS. The highest serum concentration of platinum is 30 percent of that of the injection group. The platinum concentration was increased in liver (P < 0.01) and decreased in kidney (P < 0.05) vs that of injection group.