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Updated: Aug 10, 2026

Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography
Published on: September 14, 2014
ATP synthase subunit C storage in the polymorphonucleocytes of late infantile and juvenile batten patients
N H Ansari1, J D Cook, P Khanna
1Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555-0355, USA.
Abstract:
In late infantile and juvenile forms of neuronal ceroid lipofuscinosis, commonly known as Batten disease (BD). ATP synthase subunit c accumulates in the lysosomes of neural cells. By using polyclonal antibodies, raised against bovine liver subunit c and an image analysis system for the quantification of antibody-linked alkaline phosphatase reaction, we have demonstrated that polymorphonucleocytes (PMN) from a late infantile and a juvenile BD patient stored several-fold more subunit c as compared to normal PMN.
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