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The ovarian renin-angiotensin system. A paracrine-intracrine regulator of ovarian function
J R Pepperell1, Y Yamada, G Nemeth
1Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, Connecticut, USA.
Advances in Experimental Medicine and Biology
|January 1, 1995
Abstract:
We present a review that considers the regulation of ovarian function by the ovarian renin-angiotensin system. Evidence is presented that shows the ovarian renin-angiotensin system can regulate normal ovarian function by paracrine and intracrine mechanisms. In addition, the complexity that is inherent in the renin-angiotensin system conferred by multiple biological angiotensin peptides and multiple receptors is discussed. Evidence that a dysfunctional OVRAS induces ovarian pathology such as polycystic ovarian disease is also presented.