Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

53.3K
Overview
53.3K
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

9.2K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
9.2K
Brain Waves01:23

Brain Waves

4.2K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
4.2K
Organization of the Brain01:30

Organization of the Brain

2.7K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.7K
Brain Imaging01:14

Brain Imaging

760
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
760
Neurons as Communicators of the Brain01:22

Neurons as Communicators of the Brain

3.4K
Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Memory Part 3: The Role of the Fornix and Clinical Cases.

AJNR. American journal of neuroradiology·2015
Same author

Increased cytoplasmic accumulation of goblet cell glycoproteins in ulcerative colitis.

Inflammatory bowel diseases·2013
Same author

Review: cerebral microvascular pathology in ageing and neurodegeneration.

Neuropathology and applied neurobiology·2010
Same author

Pneumoperitoneum in the Treatment of Pulmonary Tuberculosis.

Journal of the National Medical Association·2010
Same author

The piglet as a model for B cell and immune system development.

Veterinary immunology and immunopathology·2008
Same author

A morphologic study of the vasculature of malignant gliomas using thick celloidin sections and alkaline phosphatase stain.

Clinical neuropathology·2004
Same journal

CT Evaluation of Osseous Trauma at the Craniocervical Junction: A Pattern-Based Overview.

AJNR. American journal of neuroradiology·2026
Same journal

Comprehensive Structural MRI Phenotyping in <i>Oligophrenin 1-</i>Related Disorder Reveals Characteristic Brain Malformations.

AJNR. American journal of neuroradiology·2026
Same journal

ASNR-ESNR White Paper on Sustainability in Neuroradiology.

AJNR. American journal of neuroradiology·2026
Same journal

Intracranial Atherosclerotic Disease Distribution Across Circle of Willis Segments: Insights from CREST-H.

AJNR. American journal of neuroradiology·2026
Same journal

Regional Cerebral Blood Flow Patterns on ASL in Subacute Sclerosing Panencephalitis: Quantitative Analysis and Clinical Correlation.

AJNR. American journal of neuroradiology·2026
Same journal

Improved Diagnostic Certainty of Photon-Counting CT Myelography Compared with Energy-Integrating CT for CSF-Venous Fistulas in Spontaneous Intracranial Hypotension.

AJNR. American journal of neuroradiology·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

20.9K

Brain slice holder for MR

W R Brown1, D M Moody, V P Mathews

  • 1Department of Radiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA.

AJNR. American Journal of Neuroradiology
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Researchers developed an MR-compatible brain slice holder for precise imaging and histology alignment. This device enhances safety by enclosing tissues and saves time by scanning only selected brain slices.

More Related Videos

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
10:53

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Published on: February 26, 2018

48.8K
Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
11:13

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

Published on: April 5, 2016

16.9K

Related Experiment Videos

Last Updated: Feb 13, 2026

Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

20.9K
Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
10:53

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Published on: February 26, 2018

48.8K
Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
11:13

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

Published on: April 5, 2016

16.9K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Histology

Background:

  • Accurate correlation between Magnetic Resonance (MR) imaging and histological sections is crucial for brain research.
  • Handling unfixed brain tissues poses a risk of pathogen exposure.
  • Current methods may be time-consuming or lack precise spatial correlation.

Purpose of the Study:

  • To develop and validate an MR-compatible brain slice holder.
  • To ensure precise spatial alignment between MR images and subsequent histological sections.
  • To enhance safety during tissue handling and optimize imaging protocols.

Main Methods:

  • Design and fabrication of an MR-compatible brain slice holder.
  • Utilizing the holder to enclose unfixed brain tissues.
  • Acquiring MR images of selected brain slices.
  • Comparing the location and orientation of MR images with corresponding histologic sections.

Main Results:

  • The developed holder ensures accurate location and orientation matching between MR images and histologic sections.
  • Enclosing unfixed tissues within the holder significantly reduces the risk of pathogen exposure.
  • Scanning selected slices, rather than the whole brain, saves considerable MR imaging time.
  • The technique is particularly effective for brain sections at varying angles.

Conclusions:

  • The MR-compatible brain slice holder is a valuable tool for neuroimaging and histology.
  • It improves the safety and efficiency of brain tissue analysis.
  • This method facilitates precise spatial correlation for advanced neuropathological studies.