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No evidence for allelic association between bipolar disorder and monoamine oxidase A gene polymorphisms
N Craddock1, J Daniels, E Roberts
1Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom.
American Journal of Medical Genetics
|August 14, 1995
Abstract:
We have tested the hypothesis that DNA markers in the MAOA gene show allelic association with bipolar affective disorder. Eighty-four unrelated Caucasian patients with DSM III-R bipolar disorder and 84 Caucasian controls were typed for three markers in MAOA: a dinucleotide repeat in intron 2, a VNTR in intron 1, and an Fnu4HI RFLP in exon 8. No evidence for allelic association was observed between any of the markers and bipolar disorder.