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Related Experiment Videos

Gender-specific second-trimester biometry

J C Smulian1, W A Campbell, J F Rodis

  • 1Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, USA.

American Journal of Obstetrics and Gynecology
|October 1, 1995
PubMed
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This study found small, statistically significant gender differences in fetal biometry measurements during the second trimester. These differences are generally not clinically significant, suggesting limited value for gender-specific fetal growth charts.

Area of Science:

  • Prenatal diagnostics
  • Fetal biometry
  • Medical imaging

Background:

  • Accurate fetal biometry is crucial for assessing gestational age and fetal well-being.
  • Previous studies have explored various fetal parameters, but the impact of fetal sex on these measurements requires further clarification.

Purpose of the Study:

  • To evaluate the significance of gender differences in common biometric parameters obtained via ultrasound in euploid fetuses during the second trimester.
  • To determine if these differences are clinically relevant for routine obstetric assessments.

Main Methods:

  • Developed gender-specific linear regression equations for gestational age-dependent and independent biometry.
  • Utilized biparietal diameters, femur lengths, and humerus lengths from 539 euploid fetuses (288 male, 251 female).

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  • Compared regression lines between male and female fetuses using 95% confidence intervals.

    • Main Results:

    • Identified small, statistically significant gender differences in fetal biometry.
    • The largest gestational age-dependent difference was 1.15 mm in biparietal diameter at 21 weeks.
    • The largest gestational age-independent difference was 1.7 mm in femur length at a biparietal diameter of 50 mm.

    Conclusions:

    • Statistically significant, yet small, gender differences exist in second-trimester fetal biometry.
    • These differences are unlikely to be clinically significant, indicating limited utility for gender-specific nomograms.
    • Ultrasound biometry in euploid fetuses shows minimal sex-based variation impacting clinical interpretation.