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Related Experiment Videos

Vortex keratopathy associated with atovaquone

G K Shah1, H L Cantrill, E J Holland

  • 1Department of Ophthalmology, University of Minnesota Hospital and Clinics, USA.

American Journal of Ophthalmology
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

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Atovaquone, a medication for Pneumocystis pneumonia in AIDS patients, can cause vortex keratopathy. This drug-induced corneal condition is linked to atovaquone

Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Acquired immunodeficiency syndrome (AIDS) requires treatment for opportunistic infections like Pneumocystis pneumonia.
  • Atovaquone is an effective agent against Pneumocystis pneumonia.

Observation:

  • A case of vortex keratopathy was observed in an AIDS patient undergoing atovaquone treatment.
  • The patient received 750 mg of atovaquone thrice daily.

Findings:

  • Atovaquone-induced vortex keratopathy presents similarly to other drug-induced cases.
  • The lipophilic nature of atovaquone is presumed to be the cause, similar to agents like amiodarone and chloroquine.

Implications:

  • Atovaquone should be recognized as a potential cause of vortex keratopathy.

Related Experiment Videos

  • Clinicians should consider atovaquone when diagnosing drug-induced corneal changes.