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Interleukin-10 in the vitreous of patients with primary intraocular lymphoma
C C Chan1, S M Whitcup, D Solomon
1Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892-1858, USA.
Purpose:
To find an accurate and simple method to diagnose primary intraocular lymphoma.
Methods:
We prospectively analyzed concentrations of interleukin-10, interleukin-1, interleukin-2, interleukin-4, and interleukin-6 in vitrectomy specimens from three patients with primary intraocular lymphoma and five patients with uveitis by enzyme-linked immunosorbent assay.
Results:
Interleukin-10 in the vitreous was detected in patients with primary intraocular lymphoma. Interleukin-10 levels correlated with clinical activity and the number of malignant cells.
Conclusion:
Concentrations of interleukin-10 in the vitreous may be a helpful clue to both clinicians and pathologists in diagnosing primary intraocular lymphoma.
