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Ventral ectodermal ridge and ventral ectodermal groove: two distinct morphological features in the developing rat

S Gajović1, L Kostović-Knezević

  • 1Department of Histology and Embryology, Faculty of Medicine, University of Zagreb, Croatia.

Anatomy and Embryology
|August 1, 1995
PubMed
Summary

The ventral ectodermal ridge (VER) and ventral ectodermal groove (VEG) are transient embryonic tail structures in rats. The VER forms and then undergoes cell death, while the VEG flattens and disappears during development.

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Area of Science:

  • Embryology
  • Developmental Biology
  • Comparative Anatomy

Background:

  • The ventral ectodermal ridge (VER) is a transient embryonic structure in the rat tail.
  • It shares morphological similarities with the apical ectodermal ridge of limb buds.
  • Its developmental role and characteristics are not fully understood.

Purpose of the Study:

  • To investigate the morphological characteristics of the VER and associated structures in developing rat embryos.
  • To describe the developmental timeline and cellular interactions of the VER and ventral ectodermal groove (VEG).

Main Methods:

  • Light microscopy of serial semithin sections.
  • Scanning and transmission electron microscopy.
  • Observation of rat embryos aged 10.5 to 14 days.

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Main Results:

  • The ventral ectodermal thickening comprises the VER (elevated posterior) and VEG (concave anterior).
  • Cellular contacts between VER and mesenchyme occur until basal lamina formation at 11.5 days.
  • The VEG flattens and disappears by 12 days; the VER peaks in height and undergoes apoptosis, vanishing by 14 days.

Conclusions:

  • The VER and VEG are distinct, transient structures in rat embryonic tail development.
  • The VER exhibits programmed cell death, suggesting a role in tail morphogenesis.
  • Further research is needed to elucidate the precise functions of these structures.