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Reproducibility (precision) in alternate site testing. A clinician's perspective

N B Watts1

  • 1Emory University School of Medicine, Atlanta, Ga, USA.

Archives of Pathology & Laboratory Medicine
|October 1, 1995
PubMed
Summary

Test quality involves more than reproducibility. Analytic precision needs vary based on clinical context, patient population, and test application for optimal use.

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Point-of-Care Testing

Background:

  • Test quality assessment traditionally focuses on reproducibility.
  • Evaluating tests for point-of-care settings requires a broader quality perspective.

Purpose of the Study:

  • To examine the role of analytic precision in evaluating point-of-care testing.
  • To determine how precision requirements vary with clinical application.

Main Methods:

  • Review of relevant scientific literature.
  • Analysis of personal experience in clinical laboratory settings.

Main Results:

  • Hemoglobin A1c and bedside glucose measurements illustrate differing precision needs.
  • Alternate site testing methodologies require careful consideration of precision's importance.

Conclusions:

  • The necessity of analytic precision is context-dependent, varying with test purpose, patient population, and clinical interpretation.
  • Precision can be adjusted for factors like cost, availability, and speed, but clinical relevance must guide decisions.
  • Effective laboratory service utilization necessitates collaboration between laboratory professionals and clinicians.

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