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Structure-activity relationships in a series of 8-substituted xanthines as bronchodilator and A1-adenosine receptor
S Corsano1, G Strappaghetti, R Scapicchi
1Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università di Perugia, Italy.
Archiv Der Pharmazie
|September 1, 1995
Abstract:
Four new derivatives of 8-piperazine ethyl xanthine were synthesized and their bronchospasmolytic activity and A1-adenosine affinity were studied. Their relaxant action in the tracheal muscle was lower than that of theophylline and that of theophylline derivatives substituted at the 7-position. Only compound 9, where the methyl group in the 1-position of the theophylline was substituted by an isobutyl group, shows a good affinity towards the A1-adenosine receptor.