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Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
Published on: May 18, 2009
Family of cyclic nucleotide gated ion channels
1Institut für Biologische Informationsverarbeitung, Forschungszentrum Jülich, Germany.
Abstract:
A variety of different cyclic nucleotide gated ion channels have recently been identified using molecular cloning and electrophysiological techniques. Current research is focussed on the specific molecular determinants that endow these channels with their distinctive character of gating, selectivity and modulation. In some cases, it has been possible to identify the specific physiological roles of different cyclic nucleotide gated channels. Their interactions with Ca2+ and calmodulin are particularly important, and determine the specific functions these channels subserve in distinct cells.
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