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Automated method for determining Instron Residual Seal Force of glass vial/rubber closure systems. Part II. 13 mm
1Burroughs Wellcome Company, Pharmaceutical Development Laboratories, Greenville, North Carolina, USA.
PDA Journal of Pharmaceutical Science and Technology
|September 1, 1995
Abstract:
Instron Residual Seal Force (IRSF) of 13 mm glass vial/rubber closure systems was determined using an Instron 4501 Materials Testing System and computerized data analysis. A series of three cap anvils varying in shape and dimensions were machined to optimize cap anvil performance. Cap anvils with spherical top surfaces and narrow internal dimensions produced uniform stress-deformation curves from which precise IRSF values were derived.

