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Distribution and correlates of insulin in elderly men. The Honolulu Heart Program
C M Burchfiel1, J D Curb, D S Sharp
1Honolulu Epidemiology Research Unit, National Heart, Lung, and Blood Institute, HI 96817, USA.
Arteriosclerosis, Thrombosis, and Vascular Biology
|December 1, 1995
Summary
Insulin levels in elderly Japanese American men correlate with obesity, triglycerides, and glucose. Higher insulin is linked to increased cardiovascular disease risk factors like hypertension and diabetes.
Area of Science:
- Cardiovascular Science
- Endocrinology
- Gerontology
Background:
- The relationship between insulin and cardiovascular disease (CVD) is not fully understood.
- Research on insulin's role in CVD within elderly and minority populations is limited.
Purpose of the Study:
- To investigate fasting and 2-hour insulin concentrations.
- To examine the cross-sectional associations between insulin levels and cardiovascular risk factors in elderly Japanese American men.
Main Methods:
- Analyzed data from 3562 elderly Japanese American men (aged 71-93) from the Honolulu Heart Program (1991-1993).
- Measured fasting and 2-hour insulin levels and correlated them with various cardiovascular risk factors including obesity, lipids, glucose, and blood pressure.
Main Results:
- Fasting insulin levels significantly declined with age, while 2-hour levels did not.
- Insulin correlated strongly with obesity, triglyceride, glucose, and HDL cholesterol levels.
- Elevated insulin levels were observed in men with hypertension and diabetes. Independent associations were found with BMI, triglycerides, glucose, fibrinogen, hematocrit, heart rate, diabetes, hypertension, and HDL cholesterol.
Conclusions:
- Insulin levels are associated with multiple cardiovascular risk factors in elderly Japanese American men.
- Findings highlight the complex interplay between insulin, metabolic factors, and cardiovascular health in this demographic.
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