Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New regimen for interpleural block in children

E Giaufré1, B Bruguerolle, C Rastello

  • 1Fondation Hopital Saint-Joseph, Marseille, France.

Paediatric Anaesthesia
|January 1, 1995
PubMed
Summary

This study suggests a safe new method for managing pain after pediatric thoracic surgery using continuous interpleural bupivacaine infusion. The regimen provided effective postoperative analgesia for two days.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The surgeon's viewpoint concerning Complex Regional Pain Syndrome 1].

Annales francaises d'anesthesie et de reanimation·2011
Same author

[What to do or not, after an anaesthetic accident? The point of view of the medical advisor].

Annales francaises d'anesthesie et de reanimation·2011
Same author

Penetration of ertapenem into muscle measured by in vivo microdialysis in mechanically ventilated patients.

Antimicrobial agents and chemotherapy·2011
Same author

[Chronopharmacology and psychiatric treatment].

L'Encephale·2009
Same author

[Biological rhythms and medications: a source of variability often neglected in pharmacology].

Annales pharmaceutiques francaises·2008
Same author

[Interactions of melatonin with the central nervous system].

L'Encephale·2006

Area of Science:

  • Anesthesiology
  • Pediatric Surgery
  • Pharmacology

Background:

  • Effective postoperative pain management is crucial for recovery after thoracic surgery in children.
  • Traditional analgesia methods may have limitations in providing sustained pain relief.
  • Interpleural regional anesthesia offers a targeted approach to thoracic pain control.

Purpose of the Study:

  • To evaluate the safety and efficacy of a novel interpleural bupivacaine infusion regimen for postoperative analgesia in children undergoing thoracic surgery.
  • To assess plasma and pleural bupivacaine levels to determine pharmacokinetic profiles and potential toxicity.

Main Methods:

  • Eight pediatric patients received continuous interpleural infusion of 0.1% bupivacaine.
  • Infusion rates were adjusted (0.5–1 ml.kg-1.h-1) for 48 hours based on pain scores.

Related Experiment Videos

  • Plasma bupivacaine and metabolite (PPX) levels were measured at 24 and 48 hours.
  • Pleural bupivacaine levels and orosomucoid (bupivacaine binding protein) were assessed in select patients.

    • Main Results:

    • The proposed interpleural bupivacaine regimen demonstrated safety in pediatric patients for 48 hours.
    • Pain scores guided the titration of the bupivacaine infusion, indicating effective analgesia.
    • Measured plasma bupivacaine levels remained within acceptable safety ranges throughout the study period.

    Conclusions:

    • This interpleural bupivacaine infusion regimen is a safe and effective option for postoperative analgesia following pediatric thoracic surgery.
    • The study supports the use of this method for sustained pain management, contributing to improved patient outcomes.