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Occupational asthma due to ceftazidime

S C Stenton1, J H Dennis, D J Hendrick

  • 1Chest Unit, Newcastle General Hospital, University of Newcastle-upon-Tyne, UK.

The European Respiratory Journal
|August 1, 1995
PubMed
Summary
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Occupational asthma was investigated in a worker exposed to ceftazidime, a third-generation cephalosporin antibiotic. Inhalation challenges confirmed ceftazidime induced asthmatic reactions and increased airway responsiveness, demonstrating its potential to cause occupational asthma.

Area of Science:

  • Occupational Medicine
  • Pharmacology
  • Immunology

Background:

  • A worker manufacturing ceftazidime, a third-generation cephalosporin antibiotic, experienced asthmatic symptoms.
  • Investigating the link between occupational exposure and respiratory symptoms is crucial for workplace safety.

Observation:

  • A double-blind inhalation challenge protocol was employed to assess the effects of ceftazidime.
  • Increasing doses of ceftazidime were administered to the worker under controlled conditions.

Findings:

  • Inhalation of ceftazidime led to asthmatic symptoms and late asthmatic reactions.
  • Airway responsiveness to methacholine significantly increased following ceftazidime exposure.
  • A repeat challenge with a 3.2 mg dose of ceftazidime triggered an immediate asthmatic reaction.

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Implications:

  • Ceftazidime has been demonstrated to be an inducer of occupational asthma.
  • These findings highlight the importance of stringent exposure controls in pharmaceutical manufacturing.
  • Further research into the mechanisms of antibiotic-induced asthma is warranted.