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Visual evoked potentials in NIDDM: a longitudinal study

G Moreo1, E Mariani, G Pizzamiglio

  • 1Divisione di Medicina Generale, Istituti Clinici di Perfezionamento, Milan, Italy.

Diabetologia
|May 1, 1995
PubMed
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Visual evoked potentials (VEPs) remained stable in diabetic patients over time, unlike peripheral neuropathy which progressed. VEPs may not predict the progression of diabetes-related optic pathway disease.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Endocrinology

Background:

  • Diabetes mellitus can lead to neurological complications, including optic pathway disease.
  • Visual evoked potentials (VEPs) are used to assess the function of the visual pathway.
  • Longitudinal studies are needed to understand the progression of these abnormalities.

Purpose of the Study:

  • To assess the progression of neurological abnormalities in non-insulin-dependent diabetic patients over time.
  • To evaluate the predictive value of VEP alterations in the stability and severity of diabetes-related optic pathway disease.
  • To correlate neurological findings with metabolic control.

Main Methods:

  • A longitudinal study involving 18 non-insulin-dependent diabetic patients and 35 controls.

Related Experiment Videos

  • Neurological examination, VEPs (pattern reversal), and nerve conduction velocities were assessed at baseline and after 4.6 years.
  • Metabolic control was also monitored.

    • Main Results:

    • At baseline, diabetic patients showed significantly delayed P100 wave latencies in VEPs compared to controls.
    • Peripheral neuropathy signs (clinical or neurophysiological) were present in five patients initially.
    • After follow-up, VEP alterations remained stable, but the incidence of peripheral neuropathy increased.
    • Peripheral neurological disease progression correlated positively with metabolic control.

    Conclusions:

    • Visual evoked potential alterations in non-insulin-dependent diabetic patients appear stable over a 4-6 year period.
    • Peripheral neurological disease, however, progresses in these patients and is linked to metabolic control.
    • VEPs may not be a reliable predictor for the progression of diabetes-related optic pathway disease, despite initial abnormalities.