Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colitis and colonic mucosal barrier dysfunction

K R Gardiner1, N H Anderson, B J Rowlands

  • 1Department of Surgery, Queen's University of Belfast.

Gut
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

'Working together' - A new approach to Reviewing the Quality of Postgraduate Medical Training Posts in Northern Ireland?

The Ulster medical journal·2021
Same author

Use of <sup>13</sup>C/<sup>12</sup>C to trace dissolved and particulate organic matter utilization by populations of an aquatic invertebrate.

Oecologia·2017
Same author

Two cases of primary adenocarcinoma of an ileal conduit: case reports and review of the literature.

The Ulster medical journal·2015
Same author

Extensor motoneurone properties are altered immediately before and during fictive locomotion in the adult decerebrate rat.

The Journal of physiology·2015
Same author

Integration psychophysics is not traditional psychophysics.

The Behavioral and brain sciences·2014
Same author

Some psycholinguistic aspects of person perception.

Memory & cognition·2013
Same journal

Glucagon-like peptide-1 receptor agonists versus dipeptidyl peptidase-4 inhibitors after liver resection for hepatocellular carcinoma in patients with type 2 diabetes: a target trial emulation study.

Gut·2026
Same journal

Dysregulated sphingolipid metabolismdrives pancreatic carcinogenesis through plasma membrane Kras enrichment.

Gut·2026
Same journal

USP20 promotes CD8<sup>+</sup> T cell exhaustion and impairs KRAS<sup>G12D</sup> inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer.

Gut·2026
Same journal

CTCF-rs705704-SUOX axis is important for the association between hypothyroidism and metabolic dysfunction-associated steatotic liver disease.

Gut·2026
Same journal

<i>Helicobacter pylori</i> infection, treatment and colorectal cancer risk by genetic predisposition: evidence from two randomised trials.

Gut·2026
Same journal

Correction: Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.

Gut·2026
See all related articles

Colonic inflammation significantly increases intestinal permeability and systemic endotoxin levels in rats. This mucosal barrier dysfunction is linked to colitis severity and may drive inflammatory bowel disease complications.

Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • The intestinal mucosal barrier prevents bacterial translocation.
  • Disruptions to this barrier occur in conditions like colitis.
  • Understanding barrier function is crucial for inflammatory bowel disease (IBD) research.

Purpose of the Study:

  • To investigate the relationship between colonic inflammation and mucosal barrier function.
  • To assess barrier integrity in experimental colitis models.
  • To correlate barrier dysfunction with systemic endotoxin levels and disease severity.

Main Methods:

  • Three experimental models of colitis were induced in rats: acetic acid, ethanol, and hapten.
  • Systemic endotoxin concentrations were measured.

Related Experiment Videos

  • Colonic permeability was assessed using 14C-polyethylene glycol (PEG).
  • Correlations between disease severity, permeability, and endotoxin levels were analyzed.

    • Main Results:

    • Rats with colitis showed significantly higher systemic endotoxin levels compared to controls.
    • Colonic permeability to 14C-PEG was significantly increased in acetic acid and hapten-induced colitis.
    • A positive correlation was observed between colitis severity and increased colonic permeability.
    • Systemic endotoxin levels correlated with colitis and illness severity in acetic acid-induced colitis.

    Conclusions:

    • Mucosal barrier dysfunction is a common feature of colitis, regardless of the cause or species.
    • Increased intestinal permeability and bacterial translocation contribute to systemic inflammation.
    • Barrier dysfunction may underlie the systemic inflammatory response and complications seen in inflammatory bowel disease.